General Information

  • ID:  hor005381
  • Uniprot ID:  P56619
  • Protein name:  Diuretic hormone 2
  • Gene name:  NA
  • Organism:  Tenebrio molitor (Yellow mealworm beetle)
  • Family:  Sauvagine/corticotropin-releasing factor/urotensin I family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Tenebrio (genus), Tenebrioninae (subfamily), Tenebrionidae (family), Tenebrionoidea (superfamily), Cucujiformia (infraorder), Polyphaga (suborder), Coleoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  AGALGESGASLSIVNSLDVLRNRLLLEIARKKAKEGANRNRQILLSL
  • Length:  47
  • Propeptide:  AGALGESGASLSIVNSLDVLRNRLLLEIARKKAKEGANRNRQILLSL
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates fluid secretion by the Malpighian tubules. Increases cyclic AMP production in Malpighian tubules.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P56619-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P56619-F1.pdbhor005381_AF2.pdbhor005381_ESM.pdb

Physical Information

Mass: 585057 Formula: C217H384N70O66
Absent amino acids: CFHMPTWY Common amino acids: L
pI: 11.52 Basic residues: 8
Polar residues: 13 Hydrophobic residues: 21
Hydrophobicity: -1.28 Boman Index: -8284
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 132.98
Instability Index: 2650.64 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  9622015
  • Title:  Isolation and identification of a second diuretic hormone from Tenebrio molitor.